Selected Articles by Category
Men's Health
General Biomarker Research
Cardiovascular Disease
Cancer
Biochemical staging of prostate cancer
Author: Canto EI;Shariat SF;Slawin KM;
PSA continues to be one of the most effective and widely used cancer screening tools available. Its popularity in prostate cancer screening, however, has eroded its usefulness in the staging of this disease. As more men are screened every year on a routine basis with DRE and PSA, the average PSA at diagnosis has drifted down to well below 10 ng/mL in many centers, including ours. This trend is likely to accelerate, as a PSA cut off for prompting biopsy of the prostate of 2.5 ng/mL gains more widespread acceptance. The recent realization that, at these levels, serum PSA is more reflective of the presence of BPH than of the extent of cancer and, therefore, does not provide additional staging information, has renewed the search for new biochemical markers that are capable of predicting prostate cancer stage and prognosis. Because of the heterogeneity of this disease, it is unlikely that a single biochemical marker that is capable of accurately staging all prostate cancer patients will be found. For this reason, nomograms that are capable of integrating various parameters to predict stage and prognosis will remain indispensable. As new biochemical markers that provide independent predictive information about stage or prognosis are identified, they can be incorporated into currently available nomograms. Of the biochemical markers discussed in this article, IL-6sR and TGF-beta1 are the most promising. By incorporating them into a preoperative nomogram designed to predict PSA recurrence, we found that they improved the ability to predict biochemical recurrence by a statistically and clinically significant margin. The ability to stage prostate cancer and predict response to therapy has improved dramatically over the last 3 decades. Nevertheless, there is still a need for new biochemical markers that will improve the ability to predict an individual patient's stage and response to therapy. Incorporating these new markers into nomograms will enhance the ability to provide optimal care for each prostate cancer patient
Preventing male osteoporosis: prevalence, risks, diagnosis and imaging tests
Author: Moyad MA;
There is no universal definition of an osteoporotic fracture. Fractures of the vertebra, hip, and forearm generally are considered osteoporotic fractures. There is an increasing recognition, however, that osteoporosis can lead to fractures at other anatomic sites, including the ribs, humerus, tibia, pelvis, and femur. Excluding these types of fractures could underestimate the total cost and impact of osteoporosis. There are a variety of risk factors for osteoporosis and fracture, but several methods can quantify a patient's risk, and these tools are valuable in guiding clinicians in effective intervention. The author hopes this brief review provides clinicians with an introduction and overview of osteoporosis and its risk factors, screening methods, and procedures. The field of urology is constantly evolving, with a growing need for clinicians to become more knowledgeable about preventive medicine. This and other articles should provide a good foundation for clinicians to alter the increasing prevalence of a medical condition that is one of the most preventable causes of morbidity and mortality in men